Research Papers

A. Kawasumi-Kita, S.-W. Lee, D. Ohtsuka, K. Niimi, Y. Asakura, K. Kitajima, Y. Sakane, K. Tamura, H. Ochi, K.-i. T. Suzuki, Y. Morishita, "hoxc12/c13 as key regulators for rebooting the developmental program in Xenopus limb regeneration" ",Nature Communications, 15:3340 (2024)

Y. Morishita, S.-W. Lee, T. Suzuki, H. Yokoyama, Y. Kamei, K. Tamura, A. Kawasumi-Kita, "An archetype and scaling of developmental tissue dynamics across species " ",Nature Communications, 14, Article number: 8199 (2023)

D. Ohtsuka, N. Kida, S.-W. Lee, N. Kawahira and Y. Morishita, "Cell disorientation by loss of SHH-dependent mechanosensation causes cyclopia", Science Advances, 8, eabn2330 (2022),

S.-W. Lee and Y. Morishita, "Two types of critical cell density for mechanical elimination of abnormal cell clusters from epithelial tissue", PLoS Computational Biology, 18(6): e1010178 (2022)

K. Kitajima, N. Kawahira, S-W. Lee, K. Tamura, Y. Morishita, D. Ohtsuka, "Light-induced local gene expression in primary chick cell culture system",Dev. Growth. Differ, 63:189-198, 2021

T. Yamada, K. Hironaka, O. Habara, Y. Morishita, T. Nishimura, "A developmental checkpoint directs metabolic remodelling as a strategy against starvation in Drosophila", Nature Metabolism, doi:10.1038/s42255-020-00293-4, 2020

N. Kawahira, D. Ohtsuka, N. Kida, K. Hironaka, and Y. Morishita, "Quantitative Analysis of 3D Tissue Deformation Reveals Key Cellular Mechanism Associated with Initial Heart Looping", Cell Reports, 30, 3889-3903, 2020"

S. Lee and Y. Morishita, "Critical contractility and cell size for mechanical cell elimination from epithelial tissue", Physical Review E, 100, 032407, 2019

N. Yakushiji-Kaminatsui, T. Kondo, K. Hironaka, J. Sharif, T. Endo, M. Nakayama, O. Masui, Y. Koseki, K. Kondo, O. Ohara, M. Vidal, Y. Morishita, and H. Koseki, "Variant PRC1 competes with retinoic acid- related signals to repress Meis2 in the mouse distal forelimb bud", Development, 145, dev166348. doi:10.1242/dev.166348, 2018

Hasugata R, Hayashi S, Kawasumi-Kita A, Sakamoto J, Kamei Y, Yokoyama H., "Infrared Laser-Mediated Gene Induction at the Single-Cell Level in the Regenerating Tail of Xenopus laevis Tadpoles", Cold Spring Harbor Protocols, 2018.

Kida, N. and Morishita, Y. "Continuum mechanical modeling of developing epithelial tissues with anisotropic surface growth", Finite Elements in Analysis and Design, 144:49-60, 2018.

A. Kawasumi-Kita, D. Ohtsuka, Y. Morishita, "Morphometric staging of organ development based on cross sectional images", J. Theor. Biol., 440, 80-87,2018.

S-W. Lee and Y. Morishita, "Possible roles of mechanical cell elimination intrinsic to growing tissues from the perspective of tissue growth efficiency and homeostasis", PLOS Comp. Biol., 13(7): e1005651, doi: 10.1371/journal.pcbi.1005651

T. Suzuki, Y. Morishita, "A quantitative approach to understanding vertebrate limb morphogenesis at the macroscopic tissue level", Current Opinion in Genetics & Development, 45: 108-114, 2017.

Y. Morishita, K. Hironaka, S.-W. Lee, T. Jin, D. Ohtsuka, "Reconstructing 3D deformation dynamics for curved epithelial sheet morphogenesis from positional data of sparsely-labeled cells", Nature Communications, 8,15 DOI: 10.1038/s41467-017-00023-7, 2017.

Hironaka, K. and Morishita, Y. Adaptive significance of critical weight for metamorphosis in holometabolous insects, Journal of Theoretical Biology, 417:68-83, 2017.

Ritsuko Morita, Miho Kihira, Yousuke Nakatsu, Yohei Nomoto, Miho Ogawa, Kazumasa Ohashi, Kensaku Mizuno, Tetsuhiko Tachikawa, Yukitaka Ishimoto, Yoshihiro Morishita, Takashi Tsuji. Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations, PLOS ONE, 0161336, 2016.

Aiko Kawasumi, Toshinori Hayashi,Takuya Kobayashi,Chikashi, Nagayama, Shinichi Hayashi, Yasuhiro Kamei, Yoshihiro Morishita, Takashi Takeuchi, Koji Tamura,Hitoshi Yokoyama, "Application of local gene induction by infrared laser-mediated microscope and temperature stimulator to amphibian regeneration study", Development Growth and Differentiation,57: 601-613, 2015.

M. Barber, Y. Arai, Y. Morishita, L. Vigier, F. Causeret, U. Borello, F. Ledonne, E. Coppola, V. Contremoulins, F. W. Pfrieger, F. Tissir, S. Govindan, D. Jabaudon, V. Proux-Gillardeaux, T. Galli. and A. Pierani, "Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Controls the Size of Higher-Order Cortical Areas", Current Biology,25:2466-2478, 2015

Morishita, Y. Kuroiwa, A. and Suzuki, T. "Quantitative analysis oftissue deformation dynamics reveals three characteristic growth modes and globally-aligned anisotropic tissue deformation during chick limb development", Development, 142: 1672-1683 (2015)

Ishimoto, Y. and Morishita, Y.　Bubbly vertex dynamics: A dynamical and geometrical model for epithelial, tissues with curved cell shapes,Physical Review E, 90, 052711 (2014)

Morishita, Y. and Suzuki, T. Bayesian inference of whole-organ deformation dynamics from limited space-time point data, Journal of Theoretical Biology, 357: 74-85,(2014)

Lee, S.W. Feugier,F.G. and Morishita, Y. Canalization-based vein formation in a growing leaf, Journal of Theoretical Biology, 353: 104-120, (2014)

Hironaka, K. and Morishita, Y. Cellular sensory mechanisms for detecting specific fold-changes inextracellular cues, Biophysical Journal, 106: 279-288, (2014)

Morishita, Y. and Hironaka, K. (Review) A systems approach to developmental biology - Designs for robust patterning -, IET Systems Biology, 7:38-49, (2013)

Hironaka, K. and Morishita, Y. (Review) Encoding and decoding of positional information in morphogen-dependent patterning, Current Opinion in Genetics & Development, 22: 553?56, (2012)

Hironaka, K. Iwasa, Y. and Morishita, Y. Multiple feedback loops achieve robust localization of wingless expression in Drosophila notum development, J. Theor. Biol., 292: 18-29, (2012)

Morishita, Y. and Iwasa, Y. Coding design of positional information for robust morphogenesis, Biophysical Journal, 101: 2324-2335, (2011)

Uriu, K. Morishita, Y. and Iwasa, Y. Random cell movement promotes synchronization of segmentation clock, PNAS, 107: 4979-4984, (2010)

Uriu, K. Morishita, Y. and Iwasa, Y. Synchronized oscillation of the segmentation clock gene in vertebrate development, J. Math. Biol., 61:207-229, (2010)

Hirashima, T. Iwasa, Y. and Morishita, Y. Mechanisms for split localization of Fgf10 expression in early lung development, Developmental Dynamics, 238: 2813-2822, (2009)

Morishita, Y. and Iwasa, Y. Accuracy of positional information provided by multiple chemical gradients with correlated noises,Phys. Rev. E, 79: 061905, (2009)

Hirashima, T. Iwasa, Y. and Morishita, Y. Dynamic modeling of branching morphogenesis of ureteric bud in early kidney development, J. Theor. Biol., 259:58-66, (2009)

Uriu, K. Morishita, Y. and Iwasa, Y. Traveling wave formation in vertebrate segmentation. J. Theor. Biol.,　257: 385-396, (2009)

Morishita, Y. and Iwasa, Y. Estimating the spatio-temporal pattern of volumetric growth rate from fate maps in chick limb development. Developmental Dynamics, 238: 415-422, (2009) Erratum: Dev. Dyn. 238: 1017-1019, (2009)

Morishita, Y. and Iwasa, Y. Growth based morphogenesis of vertebrate limb bud, Bull. Math. Biol., 70: 1957-1978, (2008)

Morishita, Y. and Iwasa, Y. Optimal placement of multiple morphogen sources, Physical Review E, 77: 041909, (2008)

Hirashima, T. Iwasa, Y. and Morishita, Y. Distance between AER and ZPA is defined by feed-forward loop and is stabilized by their feedback loop in vertebrate limb bud, Bull. Math. Biol., 70: 438-459, (2008)

Morishita, Y. Kobayashi, Tetsuya J. and Aihara, K. An Optimal Number of Signaling Molecules for Signal Amplification and Discrimination in a Chemical Cascade, Biophysical Journal, 91, pp. 2072-2081, (2006).

Morishita, Y. Kobayashi, Tetsuya J. and Aihara, K. Evaluation of the performance of mechanisms for noise attenuation in a single gene expression, J. Theor. Biol., 235, pp. 241-264, (2005).

Morishita, Y. and Aihara, K. Noise-reduction through interaction in gene expression and biochemical reaction processes, J. Theor. Biol, 228, pp. 315-325, (2004).

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Books (Japanese)

森下喜弘．
「理論生物学-生命科学の新しい潮流」　望月敦史（編）４章３節　共立出版

森下喜弘．
形態形成のシミュレーター「数理科学事典 第二版」 Ⅱ４章４節，丸善

小林徹也，有田正規，森下喜弘，合原一幸．
細胞のシステム的理解.今理論に何が求められているのか？「システム/制御/情報」(2006/8)

小林徹也，森下喜弘，富岡亮太，合原一幸．
細胞内ゆらぎの数理「システム/制御/情報」(2006/8)

小林徹也，森下喜弘，冨岡亮太，合原一幸．
細胞内ネットワークの確率的ゆらぎとその数理的解析.
　　　　　「(１分子)生物学 - 生命システムの新しい理解 」岩波書店，pp. 161-180.

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